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Suicide: - The possibility of a suicide attempt is inherent in depression and may persist until remission occurs. Therefore, high risk patients should be closely supervised throughout therapy and cons
ideration should be given to the possible need for hospitalization. In order to minimize the opportunity for overdosage, prescriptions for paroxetine should be written for the smallest quantity of dru
g consistent with good patient management.
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Adverse Effects
Adverse Events Leading to Discontinuation of Treatment: - 16% (656/4126) of patients who received paroxetine in worldwide clinical trials discontinued treatment due to an adverse experience. The most
common events (reported by at least 1% of subjects) associated with discontinuation included: asthenia, headache, nausea, somnolence, insomnia and abnormal ejaculation. All other events associated wit
h discontinuation occurred at rates of 1% or less.
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Precautions while Using this Medicine
Do not take Paxil if you have taken a monoamine oxidase (MAO) inhibitor (furazolidone, phenelzine, procarbazine, selegiline, tranylcypromine) in the past 2 weeks. Do not start taking an MAO inhibitor
within 2 weeks of stopping Paxil. If you do, you may develop confusion, agitation, restlessness, stomach or intestinal symptoms, sudden high body temperature, extremely high blood pressure, severe con
vulsions, or the serotonin syndrome.
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Overdose
Overdose attempts have been reported with paroxetine; up to 850 mg alone and in combination with other agents. In cases where paroxetine was used alone, no deaths have occurred and recovery was medica
lly uneventful.
Symptoms of overdosage with paroxetine include nausea, vomiting, tremor, dilated pupils, dry mouth and irritability. There are no reports of ECG abnormalities, coma or convul
sions following overdosage with paroxetine alone.
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Proper Use of This Medicine
Paxil is taken once a day, with or without food, usually in the morning. Inform your doctor if you are taking or plan to take any prescription or over-the-counter drugs, since they may interact unfavo
rably with Paxil.
Shake the oral suspension well before using.
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Side Effects
More common side effects may include:
- Abnormal ejaculation, abnormal orgasm, constipation, decreased appetite, decreased sex drive, diarrhea, dizziness, drowsiness, dry mouth, gas, impotence, m
ale and female genital disorders, nausea, nervousness, sleeplessness, sweating, tremor, weakness, vertigo
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